We're Dedicated to Crafting Better Beer Find your new favorite beer at our brewery in Hannibal, MO Do you love Tom Sawyer, Huckleberry Finn and beer? If so, you've come to the right place. At Mark Twain Brewing Company in Hannibal, MO, we take great pride in being located across the street from the boyhood home of Mark Twain. Our goal is to craft beer as flavorful as the man himself. Whether you need a cold drink after a long day or need a place to host your company's beer club, you should make us your go-to place for a fresh brew. Call 573-406-1300 now to learn more about our local brewery.